Use of cyclic bioisosteres of purine system derivatives for the treatment of diseases caused by disorders of nitrergic and dopaminergic systems

摘要

The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula
R 1 = -H, -NH 2 , -Br, -C1, -OH, -COOH,
B = -N=, -CH=, Z = -CH=, -N=,
A = -N= at B = -N=, Z = -CH-,
A = -CH= at B = -N=, Z = -CH-,
A = -CH= at B = -N=, Z = -N=,
A = -CH= at B = -CH=, Z = -CH=,
A = -CH= at B = -CH=, Z = -N= ,
and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.