| 发明名称 |
Hepatitis C virus vaccine |
| 摘要 |
The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
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| 申请公布号 |
US7598362(B2) |
申请公布日期 |
2009.10.06 |
| 申请号 |
US20040492178 |
申请日期 |
2004.04.07 |
| 申请人 |
MERCK & CO., INC.;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
EMINI EMILIO A.;KASLOW DAVID C.;BETT ANDREW J.;SHIVER JOHN W.;NICOSIA ALFREDO;LAHM ARMIN;LUZZAGO ALESSANDRA;CORTESE RICCARDO;COLLOCA STEFANO |
| 分类号 |
C07H21/04;C12N15/09;A61K35/76;A61K38/00;A61K39/00;A61K48/00;A61P31/14;C07K14/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/00;C12N15/40;C12N15/51;C12N15/861 |
主分类号 |
C07H21/04 |
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