发明名称 |
Process for solubilizing glucagon-like peptide 1 compounds |
摘要 |
Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
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申请公布号 |
US7598222(B2) |
申请公布日期 |
2009.10.06 |
申请号 |
US20020169657 |
申请日期 |
2002.06.28 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
PROUTY, JR. WALTER FRANCIS;RINELLA, JR. JOSEPH VINCENT |
分类号 |
A61K38/17;A61K38/26;C07K1/113;C07K1/34;C07K14/605 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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