Gene manipulation in the human PLK1 gene

摘要

In vitro method for prognosis of disease risks, course of disease, medicament risks and for detecting drug target, comprises scanning a biological sample according to one or more gene mutations in the 3'-untranslated region (3'UTR) of the gene polo-like kinase 1 (PLK1), which codes for the protein PLK1, on the human chromosome 16p12.1. Independent claims are included for: (1) a method for finding relevant polymorphisms and haplotypes in the gene PLK1 and in neighboring genes, comprising the quantification of the expression of PLK1 in connection with the polymorphism and comparison with the expression of other polymorphisms of PLK1; and (2) a kit for carrying out the method comprising primer and/or probe, which is suitable for detection of the polymorphism A11285G in the 3'UTR of the gene PLK1. ACTIVITY : Cytostatic. MECHANISM OF ACTION : PLK1 inhibitor.