Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
申请公布号
EP2102340(A2)
申请公布日期
2009.09.23
申请号
EP20070862213
申请日期
2007.11.27
申请人
ISIS PHARMACEUTICALS, INC.
发明人
FREIER, SUSAN M.;CROOKE, ROSANNE M.;GRAHAM, MARK J.;TARBET, KRISTINA LEMONIDIS;BHANOT, SANJAY;TRIBBLE, DIANE;WATT, ANDREW T.