发明名称 |
OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR THE USE IN MODULATION OF MICRORNAS |
摘要 |
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activity in a cell.
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申请公布号 |
US2009221685(A1) |
申请公布日期 |
2009.09.03 |
申请号 |
US20070161286 |
申请日期 |
2007.01.27 |
申请人 |
ISIS PHARMACEUTICALS, INC |
发明人 |
ESAU CHRISTINE;SWAYZE ERIC E.;BHAT BALKRISHEN;KINBERGER GARTH A. |
分类号 |
A61K31/7088;A61P35/00;C07H21/00;C12N15/11;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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地址 |
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