COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES TO NUCLEIC ACIDS

摘要

The present invention is directed to methods and compositions for modulating an immune response generated by a subject in response to the administration of a nucleic acid. The invention includes methods and compositions for enhancing an immune response generated by the administration of an immunostimulatory oligonucleotide by coadministration of a lipid particle, as well as methods of reducing an immune response generated by the administration of a nucleic acid by coadministration of an inhibitor of a src family kinase.