ANTIBODY AGAINST HUMAN IL-12

摘要

PROBLEM TO BE SOLVED: To provide a human IL-12 having a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer-specific IL-12 monoclonal antibodies.

SOLUTION: The heterodimer-specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer-specific IL-12 antibodies neutralize rhesus macaque IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity making them useful IL-12 antagonists.

COPYRIGHT: (C)2009,JPO&INPIT