| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To obtain a method whereby contaminants, including isomers, such as enantiomers and diastereoisomers, in a synthetic antimicrobial agent of the quinolone type can be conveniently and accurately identified and analyzed and, moreover, separated and purified, without resorting to an explosive reagent under restriction of use such as sodium perchlorate. <P>SOLUTION: In the high performance liquid chromatography method, use is made of a mobile phase wherein copper ions, an amino acid, ammonium acetate and an organic solvent are contained in water. It allows for the analysis of a column packed with octadecyl silica gel and is useful. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
