N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE NICOTINATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

Disclosed herein are a novel nicotinic acid salt of N,N-dimethyl imidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are the nicotinic acid salt of N,N-dimethyl imidodicarbonimidic diamide, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also of p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as the preparation method thereof and the pharmaceutical composition comprising the same.