| 摘要 |
1280788 3 - Octadecyloxy - propan - 1 - ol derivatives DR KARL THOMAE GmbH 19 April 1971 [27 Feb 1970] 22746/71 Headings C2C and C2P The novel compound 3-octadecyloxypropyl- 2<SP>1</SP>-trimethylammoniumethyl phosphate may be prepared by removal of bromide ions, with internal salt formation, from 3-octadecyloxypropyl-phosphate-monocholine ester bromide for example by reaction with silver acetate. The compound of the invention may be used as an immunological adjuvant in conventional pharmaceutical compositions, such as granules, tablets, capsules, syrups, emulsions, suspensions, drops and ampoules. 3 - Octadecyloxypropyl phosphate - monocholine ester bromide may be prepared by reacting 3- octadecyloxypropyl - 2<SP>1</SP> - bromoethyl phosphate with trimethylamine. 3 - Octadecyloxypropyl - 2<SP>1 </SP>- bromoethyl phosphate may be prepared by reacting 3-octadecyloxy-propan-1-ol with 2-bromoethyl phosphorodichloridate, and subsequently hydrolysing the product. 3 - Octadecyloxypropan - 1 - ol may be prepared by reacting 1,3-propanediol with octadecylsulphate or an octadecyl halide. |
