NONSTRUCTURAL PROTEIN NS1 AS A NOVEL THERAPEUTIC TARGET AGAINST FLAVIVIRUSES: USE OF INHIBITING MOLECULES INTERFERING WITH NS1 MATURATION OR BIOLOGICAL ACTIVITY

摘要

The secretion or biological activity of Flaviviruses, as well as the biological activity of NS1 protein from Flavivirus-infected cells, can be inhibited by contacting the cells or the protein with cholesterol inhibitors, sphingolipid inhibitors, glycosphingolipid inhibitors, or molecules comprising an amphipathic, amphiphilic, or hydrophobic region which interacts with NS1 protein.