TRIPHENYLPHOSPHONIUM DERIVATIVES FOR THE TARGETED TRANSPORT AND RELEASE OF SUBSTANCES IN MITOCHONDRIA, AND METHOD FOR THE USE THEREOF

摘要

The invention relates to triphenylphosphonium derivatives for the targeted concentration and release of substances in mitochondria as well as methods for using the same. The aim of the invention is to accumulate a much larger variety of pharmacological substances in a defined manner in mitochondria and release said substances in a targeted manner and with great specificity and effectiveness therein without causing undesired side effects. Said aim is achieved by triphenylphosphonium derivatives of general compound I according to general formula I described in claim 1, said derivatives being transported into mitochondria along with the respective bonded biologically active substance. The biologically active substance is released in the mitochondria by means of mitochondrial enzymes. The derivatives are used, for example, for inducing apoptosis in cancer cells (chemotherapy), boosting mitochondrial activity (e.g. oxidative phosphorylation), and thus delaying age-related diseases such as type 2 diabetes.