| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a means for regulating angiogenesis, i.e., a means for promoting even the angiogenesis of a group of specific subjects, e.g., the aged and the like, which is difficult to promote by conventional methods, and accurately regulating angiogenesis at a predetermined site. <P>SOLUTION: EC progenitors can be used in a method for regulating angiogenesis, i.e., the method for enhancing or inhibiting blood vessel formation, in a selected patient and in some preferred embodiments for targeting specific locations. For example, the EC progenitors can be used to enhance angiogenesis or to deliver an angiogenesis modulator, e.g. anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis. Additionally, in another embodiment, EC progenitors can be used to induce reendothelialization of an injured blood vessel, and thus reduce restenosis by indirectly inhibiting smooth muscle cell proliferation. <P>COPYRIGHT: (C)2009,JPO&INPIT |
