| 摘要 |
PROBLEM TO BE SOLVED: To provide isolatable, hydroxyapatite-targeting polymeric structures. SOLUTION: Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and the second terminus covalently bonded to a chemically reactive group, wherein the chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures and biologically active conjugates thereof are also provided. COPYRIGHT: (C)2009,JPO&INPIT
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