发明名称 |
AN IMMORTALIZED HUMAN CD4-POSITIVE CELL AND ITS USE FOR DETERMINING THE PHENOTYPE OF A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
摘要 |
The invention relates to an immortalized CD4-positive cell. According to the invention, this cell comprises a gene encoding a CXCR4 chemokine receptor that is capable of serving as a corecep- tor for entry of a Human Immunodeficiency Virus Type 1 (HIV-I) into the cell, and a gene en¬ coding a CCR5 receptor that is not capable of serving as a coreceptor for entry of a Human Im¬ munodeficiency Virus Type 1 into the cell. The invention furthermore relates to a method for the phenotypical characterization of a HIV-I, comprising providing such a cell, adding an HIV-I to the cell under conditions that allow for the entrance of the HIV-I into the cell and the replication of the virus in the cell, and measuring the replication of the HIV-I in the cell. |
申请公布号 |
WO2009063336(A3) |
申请公布日期 |
2009.09.03 |
申请号 |
WO2008IB03924 |
申请日期 |
2008.11.14 |
申请人 |
PAUL-EHRLICH-INSTITUT BUNDESAMT FUER SERA UND IMPFSTOFFE;BINNINGER-SCHINZEL, DOROTHEA;SCHNIERLE, BARBARA;WERNER, ALBRECHT |
发明人 |
BINNINGER-SCHINZEL, DOROTHEA;SCHNIERLE, BARBARA;WERNER, ALBRECHT |
分类号 |
C12N5/06;G01N33/50 |
主分类号 |
C12N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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