摘要 |
<p>Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via the P450scc (CYPl IA 1) or CYP27B 1 enzyme systems and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.</p> |
申请人 |
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION |
发明人 |
ZJAWIONY, JORDAN, K.;LI, WEI;ZBYTEK, BLAZEJ;TUCKEY, ROBERT, C.;ZJAWIONY JORDAN, K.;NGUYEN, MINH NGOC;ZMIJEWSKL MICHAL, A.;JANJETOVIC, ZORICA;SWEATMAN TREVOR, W.;MILLER, DUANE, D.;CHEN, JIANJUN |