| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to medicine and describes buffered pharmaceutical peroral composition, which contains nicotine, where claimed composition is buffered by at least one amino acid, selected from arginine, asparagines, glutamic avid, glutamine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, serine, threonine, valine, cysteic acid, N-glycylglycine and ornithine, and/or its salt, and by fact, that it contains pH-regulating compound, in the cases, when pH-regulating reservoir of said at least one amino acid and/or its salt is insufficient. Also considered are method and system of nicotine delivery in any from and application of nicotine for obtaining peroral composition, in accordance with upper said, for treatment of disease, selected from group, which consists of tobacco or nicotine addiction, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerative colitis, and body weight control after giving up smoking. ^ EFFECT: invention ensures reduction of extraneous taste of buffer agents in composition, as well as reduction of buffer agent toxicity. ^ 32 cl, 10 ex, 3 tbl |
