METHOD OF OBTAINING HIGHLY DISPERSED MELOXICAME

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to method of obtaining highly dispersed meloxicame by fast cooling of meloxicame solution in 1,4-dioxane to the temperature of liquid nitrogen with further removal of solvent from formed mixture of solid phases in vacuumed thermostated vessel at pressure <510-2 mm Hg and temperature lower than temperature of 1,4-dioxane melting. Fast cooling of solution is performed by dispersion of solution into vessel with liquid nitrogen or spraying solution on copper plate at liquid nitrogen temperature. Solvent removal is performed mainly at temperature 3C, drying being carried out in flow of dry gas (nitrogen of argon) at pressure 100 Pa. ^ EFFECT: obtaining of highly dispersed meloxicame. ^ 5 cl, 3 dwg, 2 ex