GENE AND PROTEIN FOR BIOSYNTHESIS OF TRICYCLOCOMPOUNDS

摘要

The present invention relates to a gene constituting biosynthetic loci used in biosynthesis of tricyclocompounds produced by microorganisms, particularly the Actinomycete sp., tacrolimus (FK506) and dihydrotacrolimus, which is a structural analog thereof, ascomycin (FK520), prolyl-tacrolimus (FK525), FK523 and the like, and a protein which is encoded by the gene. The gene and the protein can be used to produce and chemically modify tacrolimus, ascomycin and materials having the chemical structure related thereto and to reduce impurities.