| 摘要 |
Genetic markers for late-onset Alzheimer's disease (AD) within the TRPC4AP gene locus are provided. The genetic markers include single nucleotide polymorphisms (SNPs) and haplotypes. Methods and kits for using the disclosed genetic markers to identify, or assist in the identification of, subjects as having late-onset AD, or as having an increased risk for developing late-onset AD are provided. In a preferred embodiment the genetic markers are one or more SNPs selected from the group consisting of rs1058003, rs3746430, rs3736802, rs6088677, rs6087660, rs4911460, rs6087664, rs13042358, rs6088692, rs6120816, rs1885119, rs2065108 and rs6088727, or haplotype: rs1058003_G: rs3746430_T: rs3736802_T: rs6088677_C: rs6087660_T: rs4911460_G: rs6087664_C: rs13042358_G: rs6120816_G: rs1885119_T.
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