ARF6 AS A NEW TARGET FOR TREATING ALZHEIMER'S DISEASE

摘要

The present invention relates to the field of disorders of the peripheral or central nervous system, in particular Alzheimer's disease, and the prevention and/or treatment thereof. In particular, the present invention relates to ARF6 and/or ARF6 effector proteins as new targets in Alzheimer's disease, and based thereon screening methods for compounds that reduce amyloid beta peptide formation in mammalian cells by affecting ARF6-mediated endosomal sorting.