| 发明名称 |
ANTI-ALPHA2 INTEGRIN ANTIBODIES AND THEIR USES |
| 摘要 |
The invention relates to anti-α2 integrin antibodies and their uses. Humanized antibodies are disclosed that bind to the I domain ofα2 integrin and inhibit the interaction ofα2β1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in treatingα2β1-mediated disorders, including anti-α2 integrin antibodies that bind toα2 integrin without activating platelets.
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| 申请公布号 |
US2011135635(A1) |
申请公布日期 |
2011.06.09 |
| 申请号 |
US20100858174 |
申请日期 |
2010.08.17 |
| 申请人 |
GLENMARK PHARMACEUTICALS S.A. |
发明人 |
LAZARIDES ELIAS;WOODS CATHERINE MARY;BERNARD MARK |
| 分类号 |
A61K39/395;A61P29/00;A61P35/00;A61P37/06;C07H21/04;C07K14/705;C07K16/46;C12N1/00;C12N5/10;C12N15/63;G01N33/68 |
主分类号 |
A61K39/395 |
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