BIOLOGICAL PATHWAYS ASSOCIATED WITH CHEMOTHERAPY TREATMENT IN BREAST CANCER
摘要
The present invention provides methods for preparing drug response and/or resistance profiles for breast tumor specimens, or cells derived therefrom. The drug response and/or resistance profiles are useful for determining effective chemotherapeutic agents for treatment of the tumor or cell to thereby individualize patient therapy. In other aspects, the invention provides a method for identifying a pathway or gene expression signature indicative of a breast cancer cell's sensitivity to a chemotherapeutic agent, which is useful for identifying a population response rate, or patient sub-population likely to respond to the drug candidate.
申请公布号
CA2818133(A1)
申请公布日期
2011.06.09
申请号
CA20102818133
申请日期
2010.12.01
申请人
PRECISION THERAPEUTICS, INC.
发明人
SHEN, KUI;SONG, NAN;RICE, SHARA D.;WANG, DAKUN;GINGRICH, DAVID A.;DING, ZHENYU;TIAN, CHUNQIAO;BROWER, STACEY L.;ERVIN, PAUL R.;GABRIN, MICHAEL J.