QUINAZOLINE DERIVATIVES

摘要

Compounds represented by general formula (I), exhibiting BRAF-inhibitory activity; or pharmacologically acceptable salts thereof. In general formula (I), R1 and R2 are each H, halogen, C1-4 alkyl, or halogeno C1-4 alkyl; R3 is hydroxy, C2-4 alkynyl (which may have hydroxy or acetoxy), -NR5aR5b, azetidinyl (which may have C1-4 alkyl), oxazolidinyl (which may have oxo), pyrrolidinyl (which may have C1-4 alkyl), dioxanyl, or pyrazolyl; R5a and R5b are each H, C1-4 alkyl, or hydroxy C1-4 alkyl; R4 is H or C1-4 alkyl; n is 1 or 2; Y is C-R6 or N; and R6 is H or halogen.