PROGNOSIS, DIAGNOSIS AND IDENTIFICATION OF MULTIPLE MYELOMA BASED ON GLOBAL GENE EXPRESSION PROFILING

摘要

The present invention provides a diagnostic or prognostic indicator of multiple myeloma that comprises a global expression profile of total miRNA in the subject with a pattern of 39 up-regulated and 1 down-regulated gene as listed in Table 1. Also provided are methods of diagnosing multiple myleoma in a subject and determining prognosis of a subject with multiple myeloma by demonstrating the subject shows the expression profile of the diagnostic or prognostic indicator and further calculating a risk score and/or a proliferation level based on a group of 70 genes and 11 genes, respectively, such that high scores and levels concomitant with the miRNA expression profile correlates to a diagnosis and/or a poor prognosis. In addition, methods of treating multiple myeloma with a therapeutic inhibitor of an miRNA maturation pathway in the subject and for screening for therapeutic inhibitors that inhibit AGO2 and/or DICER1 genes are provided.