发明名称 |
Compositions and Method for Epigenetic Modification of Nucleic Acid Sequences in Vivo |
摘要 |
Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilising a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.
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申请公布号 |
US2011138491(A1) |
申请公布日期 |
2011.06.09 |
申请号 |
US20070226094 |
申请日期 |
2007.04.10 |
申请人 |
CELLCENTRIC LIMITED |
发明人 |
REIK WOLF;MORGAN HUGH;CHAN CHUN-FUNG |
分类号 |
A01K67/027;A01K67/00;A61K38/50;A61P35/00;C07H21/04;C12N5/00;C12N9/78;C12N15/63 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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