发明名称 |
LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS |
摘要 |
<p>The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.</p> |
申请公布号 |
WO2011069127(A1) |
申请公布日期 |
2011.06.09 |
申请号 |
WO2010US58990 |
申请日期 |
2010.12.03 |
申请人 |
STEM CELL & REGENERATIVE MEDICINE INTERNATIONAL, INC.;LI, FENG;LU, SHI-JIANG |
发明人 |
LI, FENG;LU, SHI-JIANG |
分类号 |
C12N5/00;C12N5/02 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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