| 发明名称 |
Heteroaryl urea derivatives useful for inhibiting CHK1 |
| 摘要 |
Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.
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| 申请公布号 |
EP2330105(A1) |
申请公布日期 |
2011.06.08 |
| 申请号 |
EP20100189889 |
申请日期 |
2006.03.29 |
| 申请人 |
ICOS CORPORATION |
发明人 |
DIAZ, FRANK;FAROUZ, FRANCINE S;HOLCOMB, RYAN COATSWORTH;KESICKI, EDWARD AMMANITO;OOI, HUA CHEE;RUDOLPH, ALEXANDER C;STAPPENBECK, FRANK;THORSETT, EUGENE DELOY;GAUDINO, JOHN JOSEPH;ASHWORTH (NEE FISCHER), KIMBA LEE;COOK, ADAM WADE |
| 分类号 |
C07D403/12;A61K31/497;A61K31/5355;A61K31/541;A61P35/00;C07D413/12;C07D417/12 |
主分类号 |
C07D403/12 |
| 代理机构 |
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