发明名称 |
IMIDAZOLE CARBONYL COMPOUND |
摘要 |
To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient. |
申请公布号 |
EP2226322(A4) |
申请公布日期 |
2011.06.08 |
申请号 |
EP20080867971 |
申请日期 |
2008.12.26 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
SONEDA, TSUYOSHI;TAKESHITA, HIROSHI;KAGOSHIMA, YOSHIKO;YAMAMOTO, YUKO;HOSOKAWA, TAKAFUMI;KONOSU, TOSHIYUKI;MASUDA, NOBUHISA;UCHIDA, TAKUYA;ACHIWA, ISSEI;KUROYANAGI, JUNICHI;FUJISAWA, TETSUNORI;YOKOMIZO, AKI;NOGUCHI, TETSUJI |
分类号 |
C07D417/14;A61K31/4164;A61K31/4178;A61K31/422;A61K31/427;A61K31/454;A61K31/4545;A61K31/506;A61K31/538;A61P31/00;A61P31/04;C07D233/66;C07D401/12;C07D401/14;C07D403/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D487/06 |
主分类号 |
C07D417/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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