Implant coating with nucleic acids

摘要

Implant comprises a coating or a cavity filling comprising a nucleic acid that inhibits the expression of at least one representative of Ras-gene family by RNA interference, or encodes a nucleic acid that inhibits the expression of at least one representative of Ras-gene family by RNA interference. An independent claim is included for the nucleic acid comprising a sequence of SEQ ID No: 4-12 (comprising one of 9 fully defined 19-47 base pair sequences given in the specification) or a sequence that is >= 80%, preferably >= 95% identical to SEQ ID No: 4-12, or its reverse complement for the prevention and/or inhibition of restenosis. ACTIVITY : Vasotropic. MECHANISM OF ACTION : None given.