8-PHENYL-6A,7,8,9,9A,10-HEXAHYDRO-6H-ISOINDOLO[5,6-G]QUINOXALINE-7,9-DIONE(PHID) WITH NEURONAL CELL DEATH INHIBITORY ACTIVITY AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASE

摘要

PURPOSE: A composition containing PHID compound(8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo[5,6-g]quinoxaline-7,9-dione) is provided to suppress Akt and c-Jun phosphorylation and to prevent and treat neurodegenerative diseases. CONSTITUTION: A PHID(8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo[5,6-g]quinoxaline-7,9-dione) compound has an activity of suppressing nerve cell apoptosis and is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating neurodegenerative diseases contains PHID compound of chemical formula 1 as an active ingredient. A health food for preventing and treating neurodegenerative diseases contains PHID compound of chemical formula 1 as an active ingredient. The health food is manufactured in the form of tablet, pill, capsule, or liquid.