发明名称 ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES
摘要 The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.
申请公布号 KR20110002853(A) 申请公布日期 2011.01.10
申请号 KR20107024354 申请日期 2009.03.31
申请人 THE GENERAL HOSPITAL CORPORATION 发明人 RAINES DOUGLAS E.;FORMAN STUART A.;MILLER KEITH W.;HUSAIN SYED SHAUKAT;COTTEN JOSEPH F.
分类号 C07D233/58;A61K31/4164;A61P23/00;C07D233/56 主分类号 C07D233/58
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