| 摘要 |
FIELD: medicine. ^ SUBSTANCE: compound contains two or more V-areas of H-chain and two or more V-areas of L-chain of monoclonal antibody, capable of recognizing receptors of thrombopoietin and their transverse suturing in intercellular mode, and representing integral antibidy or F(ab')2. Compound may specifically recogniser and transversely suture receptor of thrombopoietin, manifesting, meanwhile, same or higher agonistic action (ED50) compared to thrombopoietin. ^ EFFECT: modification of antibody molecule results in reduction of side effects caused by formation of intercellular transverse ties, and compound of invention, having properties of thrombopoietin agonist of signal transduction, may be used as preventive or medicinal agent in case of various diseases, such as blood diseases, illnesses related to reduction of platelets number, thrombopenia, which accompanies chemotherapy in case of cancer or leukaemia. ^ 7 cl, 60 dwg, 3 tbl, 8 ex |
