发明名称 |
Method of reducing glycolysis in platelet concentrates using L-carnitine, alkanoyl carnitines and salts thereof |
摘要 |
Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.
|
申请公布号 |
US7851142(B2) |
申请公布日期 |
2010.12.14 |
申请号 |
US20070770136 |
申请日期 |
2007.06.28 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
DOTTORI SECONDO;ARDUINI ARDUINO |
分类号 |
A01N1/02;A61J3/00;A61K35/14;A61K35/18;A61L2/00;C12N5/02;C12N7/01 |
主分类号 |
A01N1/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|