| 摘要 |
13-alkyl-17-beta-hydroxy-17-alpha-propadienylgona-4,9-dien-3-ones are useful as pharmaceuticals and are obtainable by a multi-step procedure, which involves carrying out a Mannich-type reaction to convert a 17-alpha-ethynyl-substituted 4,9-dien-3,17-beta diol steroid to its 17-alpha-dialkylaminopropynyl-substituted analog, which is then converted to a quaternary ammonium salt, which is then reduced using a complex metal hydride to obtain the corresponding 17-alpha-propadienyl-diol product, which is then oxidized at the 3-position to the corresponding 17-beta-hydroxy 3-keto-final product.
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