发明名称 |
Process for preparing 2,3-disubstituted indoles |
摘要 |
Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
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申请公布号 |
US7851625(B2) |
申请公布日期 |
2010.12.14 |
申请号 |
US20090487910 |
申请日期 |
2009.06.19 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
KHODABOCUS AHMAD;LU ZHI-HUI;SENANAYAKE CHRIS HUGH;WEI HANXUN;ZHANG YONGDA |
分类号 |
C07D403/04;C07D209/04;C07D235/04;C07D401/04 |
主分类号 |
C07D403/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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