发明名称 |
METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION |
摘要 |
Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors. |
申请公布号 |
WO2010120524(A3) |
申请公布日期 |
2010.12.09 |
申请号 |
WO2010US29408 |
申请日期 |
2010.03.31 |
申请人 |
ALTAIR THERAPEUTICS, INC.;ISIS PHARMACEUTICALS, INC.;GREGORY, SUSAN;KARRAS, JAMES, G.;CROSBY, JEFFREY, R.;YU, ZHENGRONG;GEARY, RICHARD, S. |
发明人 |
GREGORY, SUSAN;KARRAS, JAMES, G.;CROSBY, JEFFREY, R.;YU, ZHENGRONG;GEARY, RICHARD, S. |
分类号 |
C12N15/113;A61K48/00;C07K14/715 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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地址 |
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