INTERNAL RIBOSOME ENTRY SITE FROM MAREK' S DISEASE VIRUS

摘要

The present invention provides an internal ribosome entry site (IRES) sequence derivable from the IRES located in the 5' untranslated region (UTR) of the pl4 lytic protein from Marek's disease virus (MDV-I). The IRES may comprise the sequence shown in figure 1 or a part or variant thereof. The present invention also provides a construct comprising such an IRES and a cistron; a nucleotide sequence comprising or capable of encoding such an IRES or construct and a vector comprising such a nucleotide sequence. The vector may be used as a pharmaceutical composition.