发明名称 |
RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ |
摘要 |
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
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申请公布号 |
US2010310604(A1) |
申请公布日期 |
2010.12.09 |
申请号 |
US20090863772 |
申请日期 |
2009.01.12 |
申请人 |
MEDICAGO INC. |
发明人 |
D'AOUST MARC-ANDRE;COUTURE MANON;ORS FREDERIC;TREPANIER SONIA;LAVOIE PIERRE-OLIVIER;DARGIS MICHELE;VEZINA LOUIS-PHILIPPE;LANDRY NATHALIE |
分类号 |
A61K39/145;A01H1/00;A01H5/00;A61P31/16;C07H21/04;C07K14/11 |
主分类号 |
A61K39/145 |
代理机构 |
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地址 |
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