METHOD FOR PREPARING NON-CRYSTALLINE (+)-LANSOPRAZOLE AND (+)-LANSOPRAZOLE ALCOHOLATE USED IN SAME

摘要

A method for preparing non-crystalline (+)-lansoprazole comprises crystallizing and yielding a (+)-lansoprazole alcoholate from a C1-C3 alcohol solution in which (+)-lansoprazole is dissolved, and drying the (+)-lansoprazole alcoholate at room temperature to a temperature of 50°C. The method prepares chemically, optically, and crystally pure and reproducible non-crystalline (+)-lansoprazole which is useful as a pharmaceutical preparation for treating and preventing diseases associated with gastric acid.