发明名称 |
METHODS FOR THE DETECTION AND QUANTITATION OF THE P95 COMPONENT OF HER2/NEU (ERBB2) |
摘要 |
<p>The present disclosure relates generally to methods for the detection and quantitation of the p95 component of HER2/neu (ERbB2). Such methods may comprise assaying the biological sample for expression of HER2 ICD; assaying the biological sample for expression of a HER2 ECD; quantitating an expressed amount of the HER2 ICD and an expressed amount of the HER2 ECD in the biological sample; and determining the amount of p95 expressed in the biological sample based on a difference between the expressed amount of the HER2 ICD and the expressed amount of the HER2 ECD. The methods of the present disclosure may be used to predict whether a subject will be responsive to a receptor tyrosine kinase inhibitor and/or may be used to select subjects for inclusion/exclusion in a clinical trial.</p> |
申请公布号 |
WO2010141543(A1) |
申请公布日期 |
2010.12.09 |
申请号 |
WO2010US37015 |
申请日期 |
2010.06.02 |
申请人 |
TARGETED MOLECULAR DIAGNOSTICS, LLC;BACUS, SARAH S. |
发明人 |
BACUS, SARAH S. |
分类号 |
G01N33/48;G01N33/53 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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