发明名称 |
T CELL SUBPOPULATIONS CAPABLE OF TREATING CANCER |
摘要 |
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating lymphocytes (TILs) having a CD8+CD28−CD152− signature in a sample of the subject, wherein a frequency of TILs having the CD8+CD28−CD152− signature above a predetermined level is indicative of a positive responsiveness to cancer treatment. Other signatures reflecting responsiveness to cancer treatment are also disclosed. In addition, methods of treating cancer based on these signatures are also disclosed.
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申请公布号 |
US2010310534(A1) |
申请公布日期 |
2010.12.09 |
申请号 |
US20080679696 |
申请日期 |
2008.09.15 |
申请人 |
OVED KFIR;EDEN ERAN;AKERMAN MARTIN;NOY ROY;BESSER MICHAL;REITER YORAM |
发明人 |
OVED KFIR;EDEN ERAN;AKERMAN MARTIN;NOY ROY;BESSER MICHAL;REITER YORAM |
分类号 |
A61K35/12;A61P35/00;G01N33/50 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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