Macrocyclic oxygen linked pyrimidine derivatives

摘要

Disclosed is a macrocyclic compound of formula (I), or a salt, N-oxide, or prodrug thereof, where the substituents are as defined in the specification. Also disclosed is the use of the above compound for treating conditions affected by inhibition of a protein kinase, such as prostate cancer, retinoblastoma, malignant neoplasm of breast, malignant tumour of colon, endometrial hyperplasia, osteosarcoma, squamous cell carcinoma, non-small cell lung cancer, melanoma, liver cell carcinoma, malignant neoplasm of pancreas, myeloid leukemia, cervical carcinoma, fibroid tumour, adenocarcinoma of the colon, T-cell leukemia, glioma, glioblastoma, oligodendroglioma, lymphoma, ovarian cancer, restenosis, astrocytoma, bladder neoplasms, musculoskeletal neoplasms and Alzheimer's Disease.