发明名称 |
Quinazoline derivative |
摘要 |
This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R1 represents a lower alkyl group et al; R2 and R3 are same and different and represents hydrogen atm et al; R4 represents the substituent of the formula (II) et al; X1 represents NH, O or S; Y represents N or C; Ar is a divalent substituent derived from aryl et al, by removing two hydrogen atoms therefrom; the ring A represents a 5- or 6-membered heteroaryl group; this compounds has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for preventive or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
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申请公布号 |
US7960394(B2) |
申请公布日期 |
2011.06.14 |
申请号 |
US20050628087 |
申请日期 |
2005.05.30 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD. |
发明人 |
MIZUTANI TAKASHI;NAGASE TSUYOSHI;SATO NAGAAKI;KANATANI AKIO;TOKITA SHIGERU |
分类号 |
A01N43/00;A61K31/517;A61K31/519;A61P1/16;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P13/12;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/32;A61P25/36;A61P43/00;C07D239/70;C07D239/91;C07D401/12;C07D403/04;C07D471/04 |
主分类号 |
A01N43/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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