发明名称 |
NANOPARTICULATE CANDESARTAN CILEXETIL COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
The present invention is directed to nanostructured (nanoparticulated) Candesartan or its pharmaceutically acceptable ester, preferable Candesartan Cilexetil, or co-crystal compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Candesartan or its pharmaceutically acceptable ester, preferable Candesartan Cilexetil, or co-crystal according to the invention have an average particle size of less than about 500 nm. Candesartan Cilexetil is a prodrug, is hydrolyzed to Candesartan during absorption from the gastrointestinal tract. Candesartan is a selective AT1 subtype angiotensin II receptor antagonist. |
申请公布号 |
WO2010146409(A3) |
申请公布日期 |
2011.09.09 |
申请号 |
WO2010HU00073 |
申请日期 |
2010.06.18 |
申请人 |
NANGENEX, INC.;FILIPCSEI, GENOVEVA;OETVOES, ZSOLT;PONGRACZ, KATALIN;DARVAS, FERENC |
发明人 |
FILIPCSEI, GENOVEVA;OETVOES, ZSOLT;PONGRACZ, KATALIN;DARVAS, FERENC |
分类号 |
A61K9/14;A61K9/00;A61K9/51;A61K31/4184 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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