| 摘要 |
<p>1298218 Steroid precursors F HOFFMANNLA ROCHE & CO AG 20 Nov 1969 [22 Nov 1968] 28139/71 Divided out of 1298214 Heading C2C The invention comprises d, I and dl compounds of Formulµ Ia and Ib wherein m is 1 or 2; R<SP>1</SP> is C 1-5 primary alkyl; R<SP>2</SP> and R<SP>3</SP> are identical lower alkyl groups or one of R<SP>2</SP> and R<SP>3</SP> is H and the other is lower alkyl; Z<SP>1</SP> is carbonyl, (lower alkylenedioxy)- methylene, di - (lower alkoxy) - methylene, phenylenedioxy-methylene or a group of formula where R<SP>5</SP> is H, lower alkyl, (lower alkoxy)- (lower alkyl), phenyl-(lower alkyl), tetrahydropyran-2-yl or lower acyl and R<SP>6</SP> is H or lower aliphatic or alicyclic hydrocarbyl; and Z<SP>2</SP> is di- (lower alkoxy) - methylene, phenylenedioxymethylene, a methylene group substituted by a divalent -ORO-, -ORS-, -SRS- or -ORNH- group (where R is lower alkylene), or is a group of Formula III defined above. The term " lower" means having up to 8 carbon atoms. Compounds Ia are prepared by hydrogenation of the corresponding 9,10-unsaturated compounds (steroid numbering) which are in turn prepared as described in Specification 1,298,212. Compounds Ib are prepared by ketalization, thioketalization, iminoketalization or reduction (optionally followed by etherification or esterification) of the carbonyl group(s) in compounds Ia.</p> |
