Isoxazolidine derivatives for inhibiting the interaction of BCL proteins with binding partners

摘要

Disclosed is a tri-substituted biphenyl isoxazolidine compound of formula 1 or a pharmaceutically acceptable salt thereof; wherein m, n, o, and p, R1, R2, R3, R4, R5, R22, R23, R24 and R25 are defined in the specification for the treatment of cancer.