发明名称 |
STABILIZED INSULINOTROPIC PEPTIDES AND METHODS OF USE |
摘要 |
The present invention provides stably crosslinked insulionotropic polypeptides having superior and unexpected benefits in the treatment of conditions involving abnormal glucose homeostasis, e.g., type 2 diabetes and conditions relating to type 2 diabetes. Such benefits include, but are not limited to, extended polypeptide half-life, enhanced alpha-helicity, improved thermal stability and protease resistance, increased functional activity and pharmacologic properties, improved bioavailability when administered by any route, and improved bioavailability and gastrointestinal absorption when delivered orally, as compared to the corresponding unmodified polypeptides. The invention also provides compositions for administering the polypeptides of the invention, as well as methods for preparing and evaluating the polypeptides of the invention. |
申请公布号 |
WO2012006598(A2) |
申请公布日期 |
2012.01.12 |
申请号 |
WO2011US43465 |
申请日期 |
2011.07.08 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;WALENSKY, LOREN, D.;BIRD, GREGORY |
发明人 |
WALENSKY, LOREN, D.;BIRD, GREGORY |
分类号 |
C07K14/605;A61K38/22;A61K38/26;A61P3/10;C07K14/575;C07K14/62 |
主分类号 |
C07K14/605 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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