发明名称 |
System, method, and computer software product for genotype determination using probe array data |
摘要 |
An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. |
申请公布号 |
US8200440(B2) |
申请公布日期 |
2012.06.12 |
申请号 |
US20080123463 |
申请日期 |
2008.05.19 |
申请人 |
HUBBELL EARL A.;CAWLEY SIMON;AFFYMETRIX, INC. |
发明人 |
HUBBELL EARL A.;CAWLEY SIMON |
分类号 |
G06F19/00;G06F19/18 |
主分类号 |
G06F19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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